Journal Article

Effect of Ribavirin on the Plasma Viral DNA Load in Patients with Disseminating Adenovirus Infection

A. C. Lankester, B. Heemskerk, E. C. J. Claas, M. W. Schilham, M. F. C. Beersma, R. G. M. Bredius, M. J. D. van Tol and A. C. M. Kroes

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 11, pages 1521-1525
Published in print June 2004 | ISSN: 1058-4838
Published online June 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/420817
Effect of Ribavirin on the Plasma Viral DNA Load in Patients with Disseminating Adenovirus Infection

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Adenovirus (AdV) infections are an increasingly frequent and potentially fatal complication in allogeneic stem cell transplant recipients. To determine the antiviral potential of ribavirin in an unbiased way, 4 patients without immune recovery were prospectively analyzed by quantitative measurement of plasma AdV DNA load. Administration of ribavirin at the first signs of AdV dissemination was not accompanied by a decrease in the plasma AdV DNA load in any of these patients, and an increase in the AdV load was even documented in 3. These observations question the potential of ribavirin to improve the outcome for patients with disseminating AdV infection and support a critical evaluation of antiviral treatments for AdV infection that involves the kinetics of virus DNA load as an objective parameter of viral replication.

Journal Article.  3155 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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