Journal Article

Predictive Value of Polymerase Chain Reaction of Cerebrospinal Fluid for Detection of Epstein-Barr Virus to Establish the Diagnosis of HIV-Related Primary Central Nervous System Lymphoma

Louise C. Ivers, Arthur Y. Kim and Paul E. Sax

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 11, pages 1629-1632
Published in print June 2004 | ISSN: 1058-4838
Published online June 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/420934
Predictive Value of Polymerase Chain Reaction of Cerebrospinal Fluid for Detection of Epstein-Barr Virus to Establish the Diagnosis of HIV-Related Primary Central Nervous System Lymphoma

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Polymerase chain reaction (PCR) of cerebrospinal fluid (CSF) for detection of Epstein-Barr virus (EBV) DNA has been proposed as a minimally invasive method for establishing the diagnosis of human immunodeficiency virus-related primary central nervous system lymphoma (PCNSL). In a review of the operational characteristics of this test in our clinical practice, the positive predictive value of CSF PCR for EBV for establishing the diagnosis of PCNSL was only 29%. Of 7 patients with CSF PCR positive for EBV, 2 had PCNSL, and 5 received alternative diagnoses (specificity, 79.1%).

Journal Article.  2138 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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