Journal Article

The Pharmacogenetics of Antiretroviral Therapy: A Review of Studies to Date

Erin Quirk, Howard McLeod and William Powderly

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 1, pages 98-106
Published in print July 2004 | ISSN: 1058-4838
Published online July 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/421557
The Pharmacogenetics of Antiretroviral Therapy: A Review of Studies to Date

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Although the ever-expanding armamentarium of antiretroviral drugs has significantly decreased the morbidity and mortality due to human immunodeficiency virus infection, patients and clinicians are increasingly faced with the problems of inadequate or toxic response to therapy that may be genetically mediated. Significant evidence now exists that interindividual differences, such as efficacy of therapy, hypersensitivity reactions, and metabolic complications as a result of antiretroviral therapy, are in part genetically determined. This article reviews the significant studies published to date in the area of the pharmacogenetics of antiretroviral therapy and summarizes current trends, as well as areas where further research is needed.

Journal Article.  6621 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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