Journal Article

Vaccine Development to Prevent Cytomegalovirus Disease: Report from the National Vaccine Advisory Committee

John F. Modlin, Ann M. Arvin, Patricia Fast, Martin Myers, Stanley Plotkin and Regina Rabinovich

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 2, pages 233-239
Published in print July 2004 | ISSN: 1058-4838
Published online July 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/421999
Vaccine Development to Prevent Cytomegalovirus Disease: Report from the National Vaccine Advisory Committee

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Cytomegalovirus (CMV) infection is the most common intrauterine infection in the United States, and it exacts a heavy toll when it infects children and immunocompromised individuals. A CMV vaccine was assigned the highest priority by the Institute of Medicine in its 1999 assessment of targets for vaccine development. The priority was based on the cost and human suffering that would be alleviated by reducing the disease burden of congenital CMV infection. The National Vaccine Advisory Committee and invited experts examined the prospects for a CMV vaccine and the actions needed to bring about successful vaccine development at a National Vaccine Program Office workshop in October 2000. This article summarizes information about the changing epidemiology of CMV and immune responses to infection and immunity, and it reviews the current status of several vaccine candidates. Support of government agencies for CMV vaccine research and development is critical to address this need.

Journal Article.  4703 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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