Journal Article

<i>Phialemonium:</i> An Emerging Mold Pathogen That Caused 4 Cases of Hemodialysis-Associated Endovascular Infection

Laurie A. Proia, Mary K. Hayden, Patricia L. Kammeyer, Joanna Ortiz, Deanna A. Sutton, Thomas Clark, Hans-Josef Schroers and Richard C. Summerbell

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 3, pages 373-379
Published in print August 2004 | ISSN: 1058-4838
Published online August 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/422320
Phialemonium: An Emerging Mold Pathogen That Caused 4 Cases of Hemodialysis-Associated Endovascular Infection

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Phialemonium species are emerging as fungal opportunistic pathogens of humans; infections caused by these fungi often have a fatal outcome. We report a series of 4 patients undergoing chronic hemodialysis who developed intravascular infection with Phialemonium curvatum. All isolates were of a distinct morphological type but were shown by partial ribosomal sequencing to be closely related to reference isolates of P. curvatum. Two patients in our case series died; both developed overwhelming infection associated with fungemia and endocarditis. Recent literature corroborates our experience that Phialemonium infection presents unique diagnostic challenges and that optimal management, particularly with regard to antifungal therapy, is not known.

Journal Article.  4079 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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