Journal Article

Fever after Immunization: Current Concepts and Improved Future Scientific Understanding

Katrin S. Kohl, S. Michael Marcy, Michael Blum, Marcy Connell Jones, Ron Dagan, John Hansen, David Nalin and Edward Rothstein

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 3, pages 389-394
Published in print August 2004 | ISSN: 1058-4838
Published online August 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/422454
Fever after Immunization: Current Concepts and Improved Future Scientific Understanding

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Fever is a common clinical complaint in adults and children with a variety of infectious illnesses, as well as a frequently reported adverse event following immunization. Although the level of measured temperature indicative of a “fever” was first defined in 1868, it remains unclear what role fever has as a physiologic reaction to invading substances, how best to measure body temperature and compare measurements from different body sites, and, consequently, how to interpret fever data derived from vaccine safety trials or immunization safety surveillance. However, even with many aspects of the societal, medical, economic, and epidemiologic meanings of fever as an adverse event following immunization (AEFI) still elusive, it is a generally benign—albeit common—clinical sign. By standardizing the definition and means of assessment of fever in vaccine safety studies, thereby permitting comparability of data, we hope to arrive at an improved understanding of its importance as an AEFI.

Journal Article.  4390 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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