Journal Article

K103N Mutation in Antiretroviral Therapy—Naive African Patients Infected with HIV Type 1

Omobosola Akinsete, Diane Hirigoyen, Charles Cartwright, Ron Schut, Rami Kantor and Keith Henry

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 4, pages 575-578
Published in print August 2004 | ISSN: 1058-4838
Published online August 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/422519
K103N Mutation in Antiretroviral Therapy—Naive African Patients Infected with HIV Type 1

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Most of the information about genetic sequencing and drug susceptibility of human immunodeficiency virus type 1 (HIV-1) is derived from the study of HIV-1 subtype B. Worldwide, most people infected with HIV-1 are infected with non—subtype B viruses and live in developing countries. We report 3 cases of antiretroviral-naive African immigrants infected with HIV-1 strains possessing the K103N mutation in the reverse transcriptase gene, which confers high-level resistance to all nonnucleoside reverse transcriptase inhibitors.

Journal Article.  2107 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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