Journal Article

Nasopharyngeal Pneumococcal Carriage after Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Children with a History of Recurrent Acute Otitis Media

Reinier H. Veenhoven, Debby Bogaert, Anne G. M. Schilder, Ger T. Rijkers, Cuno S. P. M. Uiterwaal, Herma H. Kiezebrink, Muriel J. P. van Kempen, Inge J. Dhooge, Jacob Bruin, Ed P. F. IJzerman, Ronald de Groot, Wietse Kuis, Peter W. M. Hermans and Elisabeth A. M. Sanders

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 7, pages 911-919
Published in print October 2004 | ISSN: 1058-4838
Published online October 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/422651
Nasopharyngeal Pneumococcal Carriage after Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Children with a History of Recurrent Acute Otitis Media

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

Background. We recently showed that vaccination with a 7-valent pneumococcal conjugate vaccine (PCV7) followed by a 23-valent pneumococcal polysaccharide vaccine (PPSV23) failed to prevent new episodes of acute otitis media (AOM) in previously unvaccinated toddlers and children with a history of recurrent AOM. We describe in detail the impact of pneumococcal vaccinations on nasopharyngeal carriage of S. pneumoniae in this study population.

Methods. The impact of vaccination with PCV7 followed by PPSV23 on pneumococcal nasopharyngeal carriage was studied in a prospective, randomized trial involving 383 children (age range, 1–7 years) with previous AOM. Nasopharyngeal swab specimens were collected at the time of first vaccination and at 6–7-month intervals during the 26-month follow-up period.

Results. Overall, pneumococcal carriage rates did not diminish, remaining at ∼50% in both PCV7/PPSV23 and control vaccinees. A significant shift from conjugate vaccine— to nonconjugate vaccine—type pneumococci was observed in children aged 1–2 years, who received the conjugate vaccine twice before the polysaccharide vaccine was administered. Conjugate vaccine serotype carriage was not influenced in older children, who received the conjugate vaccine once before receiving the polysaccharide booster.

Conclusions. The administration of conjugate vaccines at least twice also after 2 years of age may be mandatory for reducing the carriage of conjugate vaccine serotypes in children with recurrent AOM. Polysaccharide booster vaccination did not affect nasopharyngeal colonization with serotypes not included in the conjugate vaccine.

Journal Article.  4820 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.