Journal Article

Nelfinavir Plasma Concentrations Are Low during Pregnancy

Jeannine F. J. B. Nellen, Igor Schillevoort, Ferdinand W. N. M. Wit, Alina S. Bergshoeff, Mieke H. Godfried, Kees Boer, Joep M. A. Lange, David M. Burger and Jan M. Prins

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 5, pages 736-740
Published in print September 2004 | ISSN: 1058-4838
Published online September 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/422719
Nelfinavir Plasma Concentrations Are Low during Pregnancy

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Plasma nelfinavir concentration ratios (CRs) were calculated for all pregnant (n = 27) and nonpregnant (n = 48) human immunodeficiency virus type 1—infected women receiving the drug who visited our outpatient clinic. In pregnant women, mean and median nelfinavir CRs were significantly lower (P = .02 and P = .04, respectively), and 51% of the CRs were below the clinically relevant threshold of 0.90, compared with 35% of the CRs in nonpregnant women. After we adjusted for confounders, we found that the mean nelfinavir CR was 34% lower in pregnant women (P = .02). With targeted interventions, subsequent CRs in pregnant women showed a significant increase (median increase, 0.31; P = .01).

Journal Article.  2388 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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