Journal Article

The Search for a Predictor of CD4 Cell Count Continues: Total Lymphocyte Count Is Not a Substitute for CD4 Cell Count in the Management of HIV-Infected Individuals in a Resource-Limited Setting

N. O. Akinola, O. Olasode, I. A. Adediran, O. Onayemi, A. Murainah, O. Irinoye, A. A. Elujoba and M. A. Durosinmi

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 4, pages 579-581
Published in print August 2004 | ISSN: 1058-4838
Published online August 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/422722
The Search for a Predictor of CD4 Cell Count Continues: Total Lymphocyte Count Is Not a Substitute for CD4 Cell Count in the Management of HIV-Infected Individuals in a Resource-Limited Setting

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Total lymphocyte count (TLC) has been recommended as a substitute for CD4 cell count for the management of HIV-infected individuals living in resource-limited settings. To confirm this, 151 TLCs and CD4 cell counts were obtained from 109 patients who had not yet started treatment and analyzed. CD4 cell counts of <200 cells/mm3 were found in 42 cases (37.8%) with TLCs of ⩾1200 cells/mm3. Thus, 1 in 3 individuals would have been deprived of needed treatment. Therefore, in this setting, TLC is not a reliable predictor of CD4 cell count in HIV-infected individuals.

Journal Article.  1320 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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