Journal Article

Limited Contribution of Humoral Immunity to the Clearance of Measles Viremia in Rhesus Monkeys

Sallie R. Permar, Sherry A. Klumpp, Keith G. Mansfield, Angela A. L. Carville, Darci A. Gorgone, Michelle A. Lifton, Jörn E. Schmitz, Keith A. Reimann, Fernando P. Polack, Diane E. Griffin and Norman L. Letvin

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 190, issue 5, pages 998-1005
Published in print September 2004 | ISSN: 0022-1899
Published online September 2004 | e-ISSN: 1537-6613 | DOI: https://dx.doi.org/10.1086/422846
Limited Contribution of Humoral Immunity to the Clearance of Measles Viremia in Rhesus Monkeys

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The development of an improved vaccine for controlling measles virus (MV) infections in the developing world will require an understanding of the immune mechanisms responsible for the clearance of this virus. To evaluate the role of humoral immunity in the containment of MV, rhesus monkeys were treated at the time of MV challenge with either anti-CD20 monoclonal antibody (MAb) infusion, to deplete B lymphocytes, or both anti-CD20 and anti-CD8 MAb, to deplete both B lymphocytes and CD8+ effector T lymphocytes. Although the MV-specific antibody response in CD20+ lymphocyte-depleted monkeys was delayed by >1 week, the kinetics of MV clearance did not differ from those for monkeys that received control MAb. Furthermore, unusual clinical sequelae of MV infection were not observed in these monkeys. In contrast, MV-infected rhesus monkeys depleted of both CD20+ and CD8+ lymphocytes had a prolonged duration of viremia and developed a desquamating skin rash. These findings indicate that humoral immunity plays a limited role in the control of MV replication in an MV-naive individual and suggest that new measles vaccination strategies should focus on the elicitation of cell-mediated immune responses, in addition to neutralizing antibodies, to facilitate rapid elimination of locally replicating virus.

Journal Article.  4886 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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