Journal Article

Effect of the 7-Valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Colonization by <i>Streptococcus pneumoniae</i> in the First 2 Years of Life

Faryal Ghaffar, Theresa Barton, Juanita Lozano, Luz Stella Muniz, Patricia Hicks, Vanthaya Gan, Naveed Ahmad and George H. McCracken

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 7, pages 930-938
Published in print October 2004 | ISSN: 1058-4838
Published online October 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/423379
Effect of the 7-Valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Colonization by Streptococcus pneumoniae in the First 2 Years of Life

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Background. Studies suggest that the 7-valent pneumococcal conjugate vaccine (PCV7) reduces carriage of vaccine-type (VT) Streptococcus pneumoniae (SP). We studied the effect of PCV7 on carriage of VT- and non-VT (NVT) SP, by studying the effect of PCV7 on nasopharyngeal (NP) colonization by VT and NVT SP during early childhood.

Methods. At 2 months of age, 278 infants were enrolled in this study. To determine carriage of SP, NP samples were obtained before each PCV7 dose, at 9 months of age, and 2–3 months after the booster dose of vaccine.

Results. The carriage of SP increased slightly, from 12% (95% confidence interval [CI], 8%–16%) of subjects at 2 months of age to 18% (95% CI, 13%–23%) at 4 months of age (P < .05). Carriage of SP remained in 24%–30% of subjects during subsequent months. Between the 12- and 18-month visits, the carriage rate of VT SP decreased significantly, from 18% (95% CI, 13%–23%) to 9% (95% CI, 5%–13%) of subjects (P = .001). The trend of a decrease in carriage of penicillin-nonsusceptible SP, from 16% of subjects (95% CI, 11%–21%) at the 12–15-month visit to 9% (95% CI, 5%–13%) at the 15–18-month visit, was found after the booster dose of vaccine.

Conclusion. The reduction of VT-SP colonization and replacement by NVT SP after the booster dose of vaccine suggests the possibility that widespread vaccination will result in replacement of pneumococci mainly by antibiotic-susceptible NVT SP.

Journal Article.  4442 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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