Journal Article

Randomized Trial Comparing Vaccinia on the External Surfaces of 3 Conventional Bandages Applied to Smallpox Vaccination Sites in Primary Vaccinees

Kirk H. Waibel, Edward P. Ager, Richard L. Topolski and Douglas S. Walsh

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 7, pages 1004-1007
Published in print October 2004 | ISSN: 1058-4838
Published online October 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/423967
Randomized Trial Comparing Vaccinia on the External Surfaces of 3 Conventional Bandages Applied to Smallpox Vaccination Sites in Primary Vaccinees

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

Background. Concern about accidental contact transmission after smallpox vaccination has prompted various recommendations regarding vaccination site coverage.

Methods. On days 6–8 after their first-ever smallpox vaccination, 63 adult subjects were randomized to apply a self-adhesive bandage (n = 20), gauze with adhesive tape (n = 21), or gauze with a semipermeable dressing (n = 22) over the vaccination site for a mean of 8 ± 2 h. Swabs from the external bandage surfaces and the vaccination sites were then assessed by real time vaccinia-specific polymerase chain reaction (PCR) in blinded fashion.

Results. Among 58 subjects completing the study, PCR results were positive for the vaccination site in 55 (94.8%) and on 10 swabs (17.2%) from external bandage surfaces. There were no differences among the 3 bandages (P = .57).

Conclusions. At 7 days after smallpox vaccination, a peak time for vaccinia shedding, a self-adhesive bandage was as effective as 2 bulkier, less convenient bandages in limiting PCR-detectable virus on the external surface.

Journal Article.  2671 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.