Journal Article

Native Valve Endocarditis due to <i>Candida glabrata</i> Treated without Valvular Replacement: A Potential Role for Caspofungin in the Induction and Maintenance Treatment

M. J. Jiménez-Expósito, G. Torres, A. Baraldés, N. Benito, F. Marco, J. C. Paré, A. Moreno, X. Claramonte, C. A. Mestres, M. Almela, C. García de la María, N. Pérez, W. A. Schell, G. R. Corey, J. Perfect, M. T. Jiménez de Anta, J. M. Gatell and J. M. Miró

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 7, pages e70-e73
Published in print October 2004 | ISSN: 1058-4838
Published online October 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/424018
Native Valve Endocarditis due to Candida glabrata Treated without Valvular Replacement: A Potential Role for Caspofungin in the Induction and Maintenance Treatment

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Conventional antifungal therapy for fungal endocarditis has been associated with a poor cure rate. Therefore, combined medical and surgical therapy has been recommended. However, new potent antifungal agents, such as echinocandins, could increase the medical options and, in some cases, avoid the need for surgery. We report a case of Candida endocarditis treated successfully without valve replacement with intravenous liposomal amphotericin B (total dose, 4 g) and intravenous caspofungin (a 100-mg loading dose followed by 50 mg per day for 8 weeks) as induction therapy and intravenous caspofungin (100 mg 3 times per week for 12 weeks) as maintenance therapy.

Journal Article.  1620 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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