Journal Article

New Developments in the Diagnosis and Management of Posttransplantation Lymphoproliferative Disorders in Solid Organ Transplant Recipients

Jutta K. Preiksaitis

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 7, pages 1016-1023
Published in print October 2004 | ISSN: 1058-4838
Published online October 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/424447
New Developments in the Diagnosis and Management of Posttransplantation Lymphoproliferative Disorders in Solid Organ Transplant Recipients

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Posttransplantation lymphoproliferative disorders (PTLDs) have emerged as important causes of morbidity and mortality in solid organ transplant recipients. Epstein-Barr virus (EBV) plays a major pathophysiologic role in the development of many, if not most, of the highly diverse disease states, which span the spectrum from infection to malignancy, encompassed by the term “PTLD.” Clinical presentation and biological behavior associated with PTLD are highly variable; patients experiencing primary EBV infection in the immediate posttransplantation period are most vulnerable. New insights into PTLD pathogenesis provide exciting opportunities for rational and targeted approaches to the diagnosis, prevention, and treatment of PTLD. This article highlights some of these developments and outlines unresolved and controversial issues in PTLD management.

Journal Article.  4784 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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