Journal Article

Adverse Reactions to Voriconazole

Aileen E. Boyd, Simon Modi, Susan J. Howard, Caroline B. Moore, Brian G. Keevil and David W. Denning

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 8, pages 1241-1244
Published in print October 2004 | ISSN: 1058-4838
Published online October 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/424662
Adverse Reactions to Voriconazole

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Voriconazole is a new antifungal agent effective in the treatment of invasive aspergillosis. Interpatient variation in plasma concentrations is considerable—more than 100-fold. We describe 3 patients with diverse manifestations of toxicity (e.g., hallucinations, hypoglycemia, electrolyte disturbance, and pneumonitis) possibly attributable to high voriconazole concentrations. Measurement of plasma concentrations could be helpful in optimizing voriconazole dosages.

Journal Article.  2412 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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