Journal Article

Paradoxical Inflammatory Reaction during Treatment of <i>Cryptococcus neoformans</i> var. <i>gattii</i> Meningitis in an HIV-Seronegative Woman

Lloyd Einsiedel, David L. Gordon and John R. Dyer

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 8, pages e78-e82
Published in print October 2004 | ISSN: 1058-4838
Published online October 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/424746
Paradoxical Inflammatory Reaction during Treatment of Cryptococcus neoformans var. gattii Meningitis in an HIV-Seronegative Woman

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A human immunodeficiency virus (HIV)-seronegative woman was admitted to the hospital with postpartum onset Cryptococcus neoformans var. gattii meningitis and markedly increased intracranial pressure. A poor initial response to antifungal therapy was followed, 2 months after hospital admission, by severe acute meningeal and cerebral inflammation and clearance of yeast cells from cerebrospinal fluid. This first reported case of paradoxical inflammatory reaction to C. neoformans illustrates important aspects of the host-pathogen interaction and highlights possible effects of immunomodulatory therapies.

Journal Article.  2391 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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