Journal Article

Positive Predictive Value of Gen-Probe APTIMA Combo 2 Testing for <i>Neisseria gonorrhoeae</i> in a Population of Women with Low Prevalence of <i>N. gonorrhoeae</i> Infection

Matthew R. Golden, James P. Hughes, Linda E. Cles, Karen Crouse, Katherine Gudgel, Jinxin Hu, Paul D. Swenson, Walter E Stamm and H. Hunter Handsfield

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 9, pages 1387-1390
Published in print November 2004 | ISSN: 1058-4838
Published online November 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/424880
Positive Predictive Value of Gen-Probe APTIMA Combo 2 Testing for Neisseria gonorrhoeae in a Population of Women with Low Prevalence of N. gonorrhoeae Infection

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We collected specimens from women who tested positive for Neisseria gonorrhoeae using the Gen-Probe APTIMA Combo 2 (AC2), and we performed confirmatory tests using a nucleic acid amplification test (NAAT) that targets alternate gonococcal nucleic acid sequences. Among 59,664 specimens, 280 (0.47%) had positive results using AC2; 265 of these specimens were tested using the confirmatory NAAT, of which 258 yielded positive results (positive predictive value, 97.4%; 95% confidence interval, 95.1%–98.8%). Routine confirmatory testing of specimens with positive AC2 gonorrhea test results is not indicated.

Journal Article.  1998 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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