Journal Article

Ex Vivo Characterization of Early Secretory Antigenic Target 6–Specific T Cells at Sites of Active Disease in Pleural Tuberculosis

Katalin A. Wilkinson, Robert J. Wilkinson, Ansar Pathan, Katie Ewer, Manyu Prakash, Paul Klenerman, Nick Maskell, Robert Davies, Geoffrey Pasvol and Ajit Lalvani

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 40, issue 1, pages 184-187
Published in print January 2005 | ISSN: 1058-4838
Published online January 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/426139
Ex Vivo Characterization of Early Secretory Antigenic Target 6–Specific T Cells at Sites of Active Disease in Pleural Tuberculosis

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Presence of early secretory antigenic target-6 (ESAT-6)—specific, interferon-γ—secreting T cells in blood accurately marks tuberculosis infection. In tuberculous pleural effusions from 10 patients with tuberculosis, these cells were concentrated a mean of 15-fold (standard deviation, ±6-fold), relative to their level in peripheral blood (P = .014), and displayed rapid effector function. Such cells were absent in 8 control patients with nontuberculous pleural disease. The recruitment of ESAT-6—specific T cells to inflamed tuberculous tissue demonstrates their function in vivo and suggests a novel way to diagnose tuberculous pleuritis.

Journal Article.  2655 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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