Journal Article

BK Virus Infection in Hematopoietic Stem Cell Transplant Recipients: Frequency, Risk Factors, and Association with Postengraftment Hemorrhagic Cystitis

Veronique Erard, Barry Storer, Lawrence Corey, Jennifer Nollkamper, Meei-Li Huang, Ajit Limaye and Michael Boeckh

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 39, issue 12, pages 1861-1865
Published in print December 2004 | ISSN: 1058-4838
Published online December 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/426140
BK Virus Infection in Hematopoietic Stem Cell Transplant Recipients: Frequency, Risk Factors, and Association with Postengraftment Hemorrhagic Cystitis

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Blood samples from 132 consecutive hematopoietic stem cell transplant recipients were obtained and tested weekly for BK virus DNA by use of quantitative real-time PCR. Forty-four patients (33%) developed BK viremia at a median of 41 days (range, 9–91 days) after transplantation. Patients with hemorrhagic cystitis that occurred after platelet engraftment had higher levels of viremia than did patients without hemorrhagic cystitis (median, 9.7 × 103vs. 0 copies/mL; P = .008) and patients with hemorrhagic cystitis that occurred before platelet engraftment (median, 9.7 × 103vs. 0 copies/mL; P = .0006). BK viremia also was strongly associated with postengraftment hemorrhagic cystitis in a time-dependent analysis (P = .004).

Journal Article.  2445 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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