Journal Article

Quinolones for Treatment of Nosocomial Pneumonia: A Meta-Analysis

Andrew F. Shorr, Gregory B. Susla and Marin H. Kollef

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 40, issue Supplement_2, pages S115-S122
Published in print February 2005 | ISSN: 1058-4838
Published online February 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/426191
Quinolones for Treatment of Nosocomial Pneumonia: A Meta-Analysis

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Although quinolones are often used to treat nosocomial pneumonia (NP), there have been few trials documenting their efficacy in treating NP. Given the growing use of quinolones and issues regarding resistance, we conducted a meta-analysis of all trials of quinolones for treatment of NP. We identified 5 randomized trials comparing quinolones with other agents used to treat NP. The studies varied in both quality and sample size and included a total of nearly 1200 subjects. Four of the 5 trials used ciprofloxacin, administered every 8 h, whereas the fifth used levofloxacin administered daily. In 3 trials, the comparator agent was imipenem-cilistatin, whereas, in 2 trials, ceftazadime was the comparator agent. The efficacy of quinolones and comparator antibiotics was similar, with a pooled odds ratio for clinical cure of 1.12 (95% confidence interval, 0.80–1.55). Neither microbiological eradication rates nor mortality rates varied on the basis of antimicrobial selection.

Journal Article.  4456 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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