Journal Article

Association of Histo–Blood Group Antigens and Susceptibility to Norovirus Infections

Barry H. G. Rockx, Harry Vennema, Christian J. P. A. Hoebe, Erwin Duizer and Marion P. G. Koopmans

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 191, issue 5, pages 749-754
Published in print March 2005 | ISSN: 0022-1899
Published online March 2005 | e-ISSN: 1537-6613 | DOI: https://dx.doi.org/10.1086/427779
Association of Histo–Blood Group Antigens and Susceptibility to Norovirus Infections

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Background Noroviruses (NoVs) are the leading cause of viral gastroenteritis in humans of all ages. Challenge studies that used the NoV prototype strain Norwalk virus (NV) have shown that some individuals are not susceptible to infection, suggesting the absence of a receptor. Recent studies have identified histo–blood group antigens (HBGAs) as possible receptors. Being a nonsecretor and presence of HBGA type B were associated with protection against infection with NV, a genogroup (GG) I NoV

Methods In the present retrospective study, we investigated the association between presence of HBGAs and the risk of infection with another NoV belonging to GGI (Hu/NV/I/Birmingham/93/UK). The study was done as part of an investigation of a waterborne outbreak in a group of schoolchildren and of a cohort of healthy adults. The ABH histo–blood group phenotype was determined by use of saliva or serum samples from these individuals

Results Presence of HBGA type B was significantly correlated with a lack of susceptibility to infection with GGI NoV and with an absence of antibodies. No correlation was found with GGII NoV. Although the infection rate in nonsecretors was lower, this difference was not statistically significant, and several children lacking HBGAs in saliva were found to be infected

Conclusions Individuals with the HBGA type B may be protected against infection with GGI (but not GGII) NoVs. The association between susceptibility to NoV infection and being a secretor may be restricted to GGI NoV

Journal Article.  4114 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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