Journal Article

Interleukin-12 Receptor β1 Chain Deficiency in a Child with Disseminated Tuberculosis

Namik Özbek, Claire Fieschi, Bafak T. Yilmaz, Ludovic de Beaucoudrey, Beyhan Demirhan, Jacqueline Feinberg, Yunus Emre Bikmaz and Jean-Laurent Casanova

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 40, issue 6, pages e55-e58
Published in print March 2005 | ISSN: 1058-4838
Published online March 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/427879
Interleukin-12 Receptor β1 Chain Deficiency in a Child with Disseminated Tuberculosis

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An 11-year-old girl who presented with disseminated tuberculosis associated with secondary hemophagocytosis received a diagnosis of interleukin-12 receptor β1 chain deficiency. This diagnosis of immunodeficiency should, therefore, be considered for children with disseminated tuberculosis, even in the absence of any personal or familial history of prior infection by weakly pathogenic Salmonella and Mycobacterium species.

Journal Article.  2400 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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