Journal Article

Use of Interferon-α in Patients with West Nile Encephalitis: Report of 2 Cases

Andre C. Kalil, Marcel P. Devetten, Sanjay Singh, Brandi Lesiak, David P. Poage, Kim Bargenquast, Pierre Fayad and Alison G. Freifeld

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 40, issue 5, pages 764-766
Published in print March 2005 | ISSN: 1058-4838
Published online March 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/427945
Use of Interferon-α in Patients with West Nile Encephalitis: Report of 2 Cases

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We describe 2 patients with West Nile virus (WNV) encephalitis who were treated experimentally with interferon (IFN)–α. Both patients demonstrated substantial improvement in mentation and speech on the second day of experimental therapy, and neither required endotracheal intubation or admission to the intensive care unit during hospitalization. Moreover, during the 9-month follow-up period, one patient achieved complete recovery, and the other nearly achieved complete resolution of sequelae. To our knowledge, this is the first published report of the use of IFN-α to treat WNV encephalitis. Clinical trials are underway to further define the role of this therapy in persons with WNV encephalitis.

Journal Article.  2379 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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