Journal Article

The Role of Immune Reconstitution Inflammatory Syndrome in AIDS-Related <i>Cryptococcus neoformans</i> Disease in the Era of Highly Active Antiretroviral Therapy

Samuel A. Shelburne, Jorge Darcourt, A. Clinton White, Stephen B. Greenberg, Richard J. Hamill, Robert L. Atmar and Fehmida Visnegarwala

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 40, issue 7, pages 1049-1052
Published in print April 2005 | ISSN: 1058-4838
Published online April 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/428618
The Role of Immune Reconstitution Inflammatory Syndrome in AIDS-Related Cryptococcus neoformans Disease in the Era of Highly Active Antiretroviral Therapy

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This study of human immunodeficiency virus (HIV)-infected patients coinfected with Cryptococcus neoformans found that 30% of patients who initiated highly active antiretroviral therapy developed immune reconstitution inflammatory syndrome (IRIS). Patients with C. neoformans-related IRIS had higher cerebrospinal fluid opening pressures, glucose levels, and white blood cell counts, compared with patients with typical HIV-associated C. neoformans meningitis.

Journal Article.  2200 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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