Journal Article

Acute <i>Plasmodium falciparum</i> Malaria Following Splenectomy for Suspected Lymphoma in 2 Patients

Frédéric Bidegain, Antoine Berry, Muriel Alvarez, Olivier Verhille, Françoise Huguet, Pierre Brousset, Jacques Pris, Bruno Marchou and Jean François Magnaval

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 40, issue 11, pages e97-e100
Published in print June 2005 | ISSN: 1058-4838
Published online June 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/430061
Acute Plasmodium falciparum Malaria Following Splenectomy for Suspected Lymphoma in 2 Patients

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Two black African immigrants, with no history of recent travel outside France, received a diagnosis of a malignant lymphoproliferative disorder and splenomegaly, and they subsequently underwent splenectomy. A few weeks after surgery, both patients experienced an acute episode of Plasmodium falciparum malaria, so the initial diagnosis was corrected retrospectively and changed to hyperreactive malarial splenomegaly. These cases illustrate the difficulty in distinguishing hyperreactive malarial splenomegaly from malignant lymphoproliferative disorders and therefore underline the role of the spleen in the immune system's defense against malaria.

Journal Article.  2307 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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