Journal Article

FcγRIIIb and Complement Component C7 Codeficiency in a Patient with Recurrence of Fulminant Meningococcal Septic Shock

Anne-Lise Debard, Brigitte Lamy, Guillaume Monneret, Jean-Paul Mira, Alexandre Pachot, Marion Kleijer, Marie-Françoise Aillaud, André Boibieux, Jacques Bienvenu, Gérard Carret, Gérard Fournier and Julien Bohé

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 40, issue 11, pages 1679-1683
Published in print June 2005 | ISSN: 1058-4838
Published online June 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/430065
FcγRIIIb and Complement Component C7 Codeficiency in a Patient with Recurrence of Fulminant Meningococcal Septic Shock

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Individuals with deficiencies of the late components of complement exhibit a susceptibility to the recurrence of meningococcal disease with a usually mild clinical presentation. We report the recurrence of fulminant meningococcal disease in a complement component C7–deficient patient. We found a total deficiency of FcγRIIIb on neutrophils, which could partially explain the unusually severe clinical presentation.

Journal Article.  2723 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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