Journal Article

Pilot Study Evaluating C-Reactive Protein Levels in the Assessment of Response to Treatment of Severe Bloodstream Infection

Pedro Póvoa, Luís Coelho, Eduardo Almeida, Antero Fernandes, Rui Mealha, Pedro Moreira and Henrique Sabino

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 40, issue 12, pages 1855-1857
Published in print June 2005 | ISSN: 1058-4838
Published online June 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/430382
Pilot Study Evaluating C-Reactive Protein Levels in the Assessment of Response to Treatment of Severe Bloodstream Infection

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We evaluated the usefulness of monitoring daily C-reactive protein (CRP) levels after initiation of antimicrobial therapy in 44 patients with bloodstream infection. The ratio of the CRP level during therapy to the level at the start of antimicrobial therapy (CRP ratio) was measured. A CRP ratio of >0.58 at day 4 of therapy was a marker of poor outcome (sensitivity, 0.89; specificity, 0.69). The recognition of a pattern of CRP-ratio response was useful in the prediction of individual clinical course.

Journal Article.  2135 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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