Journal Article

Does Linezolid Cause Lactic Acidosis by Inhibiting Mitochondrial Protein Synthesis?

Michio Hirano, Lluis Palenzuela, Noah M. Hahn, Robert P. Nelson, Janet N. Arno, Carol Schobert, Robert Bethel, Lisa A. Ostrowski, Manjuli R. Sharma, Partha P. Datta, Rajendra K. Agrawal and Jennifer E. Schwartz

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 40, issue 12, pages e113-e116
Published in print June 2005 | ISSN: 1058-4838
Published online June 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/430441
Does Linezolid Cause Lactic Acidosis by Inhibiting Mitochondrial Protein Synthesis?

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Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.

Journal Article.  2618 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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