Journal Article

Emerging Metallo-β-Lactamase-Mediated Resistances: A Summary Report from the Worldwide SENTRY Antimicrobial Surveillance Program

Thomas R. Fritsche, Helio S. Sader, Mark A. Toleman, Timothy R. Walsh and Ronald N. Jones

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 41, issue Supplement_4, pages S276-S278
Published in print August 2005 | ISSN: 1058-4838
Published online August 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/430790
Emerging Metallo-β-Lactamase-Mediated Resistances: A Summary Report from the Worldwide SENTRY Antimicrobial Surveillance Program

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The rates of occurrence of metallo-β-lactamase—mediated resistances in Pseudomonas aeruginosa, Acinetobacter species, and Serratia marcescens, among other gram-negative bacilli, have escalated since 2000, severely limiting treatment options in Asia, Europe, and Latin America to non–β-lactam antimicrobial classes. Clinical isolates harboring metallo-β-lactamases have also recently been reported in western Canada and in Texas, signaling the need for development of accurate diagnostic tests by clinical laboratories to detect their presence and for new, and more potent, antimicrobial agents.

Journal Article.  1619 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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