Journal Article

Subtherapeutic Ocular Penetration of Caspofungin and Associated Treatment Failure in <i>Candida albicans</i> Endophthalmitis

G. M. Gauthier, T. M. Nork, R. Prince and D. Andes

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 41, issue 3, pages e27-e28
Published in print August 2005 | ISSN: 1058-4838
Published online August 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/431761
Subtherapeutic Ocular Penetration of Caspofungin and Associated Treatment Failure in Candida albicans Endophthalmitis

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Candida endophthalmitis represents the most serious ocular complication of candidemia. The pharmacokinetics and pharmacodynamics of fluconazole, amphotericin B, and flucytosine are fairly well established in endophthalmitis therapy. There remains a paucity of clinical data regarding the utility of new antimycotic agents in the treatment of fungal chorioretinitis and endophthalmitis. We report a case of clinical failure of caspofungin in the management of Candida albicans endophthalmitis associated with poor vitreous penetration.

Journal Article.  1247 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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