Journal Article

Human Leukocyte Antigen Class II Haplotypes that Protect against or Predispose to Streptococcal Toxic Shock

Martin Llewelyn

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 41, issue Supplement_7, pages S445-S448
Published in print November 2005 | ISSN: 1058-4838
Published online November 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/431986
Human Leukocyte Antigen Class II Haplotypes that Protect against or Predispose to Streptococcal Toxic Shock

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In the United States,1.5–5.2/100,000 persons develop invasiveStreptococcus pyogenes infections each year, and ∼10%–20% of these patients go on to develop streptococcal toxic shock syndrome (STSS). Patients who develop STSS usually present with generalized erythema, conjunctivitis, and confusion. Fulminant cardiovascular shock develops over a period of a few hours, accompanied by multiorgan failure. Between 20% and 40% of patients with STSS die, compared with∼10% of patients within vasive streptococcal disease without STSS.

Journal Article.  2131 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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