Journal Article

In Vivo Development of High-Level Fluoroquinolone Resistance in <i>Streptococcus pneumoniae</i> in Chronic Obstructive Pulmonary Disease

Emilio Pùrez-Trallero, Josù María Marimón, Alberto González, María Ercibengoa and Julián Larruskain

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 41, issue 4, pages 560-564
Published in print August 2005 | ISSN: 1058-4838
Published online August 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/432062
In Vivo Development of High-Level Fluoroquinolone Resistance in Streptococcus pneumoniae in Chronic Obstructive Pulmonary Disease

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Patients with chronic obstructive pulmonary disease are generally subjected to multiple regimens of antimicrobial treatment. The development of high-level levofloxacin resistance (i.e., a minimum inhibitory concentration >8 µg/mL) in 8 patients whose previous pneumococcal isolates showed susceptibility is described. Molecular methods were used to characterize the strains and to study the sequential changes in fluoroquinolone targets.

Journal Article.  2301 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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