Journal Article

Disseminated Histoplasmosis in Persons with Interferon-γ Receptor 1 Deficiency

Christa S. Zerbe and Steven M. Holland

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 41, issue 4, pages 38-41
Published in print August 2005 | ISSN: 1058-4838
Published online August 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/432120
Disseminated Histoplasmosis in Persons with Interferon-γ Receptor 1 Deficiency

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Mutations in the interferon (IFN)–γ receptor predispose to infection with bacille Calmette-Guùrin, nontuberculous mycobacteria, and Salmonella organisms. We identified a patient with recurrent disseminated Histoplasma capsulatum osteomyelitis who had an autosomal dominant form of IFN-γ receptor 1 deficiency (i.e., a 4-bp deletion at or near base 818). IFN-γ—mediated immunity is important in the control of histoplasmosis.

Journal Article.  2916 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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