Journal Article

Successful Treatment of <i>Aspergillus</i> Prosthetic Valve Endocarditis with Oral Voriconazole

Lisa J. Reis, Todd D. Barton, Alberto Pochettino, Omaida Velazquez, Michael McGarvey, Bonnie Milas, Annette Reboli and Mindy G. Schuster

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 41, issue 5, pages 752-753
Published in print September 2005 | ISSN: 1058-4838
Published online September 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/432580
Successful Treatment of Aspergillus Prosthetic Valve Endocarditis with Oral Voriconazole

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Aspergillus endocarditis is very difficult to cure, even with aggressive surgical debridement and antifungal therapy. Patients with embolic involvement of the central nervous system have an extremely poor prognosis. We describe a patient with prosthetic valve endocarditis due to Aspergillus fumigatus who developed emboli in the brain, eye, and lower extremities. With aggressive surgical debridement of involved sites, aortic valve and root replacement, and long-term therapy with oral voriconazole, he remains without any evidence of infection 2 years later.

Journal Article.  1096 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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