Journal Article

Nonantimicrobial Agents in the Prevention and Treatment of Traveler' Diarrhea

Charles D. Ericsson

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 41, issue Supplement_8, pages S557-S563
Published in print December 2005 | ISSN: 1058-4838
Published online December 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/432952
Nonantimicrobial Agents in the Prevention and Treatment of Traveler' Diarrhea

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Among the nonantimicrobial agents that are available and useful for the prevention of traveler' diarrhea are bismuth subsalicylate—containing preparations, which can provide a rate of protection of up to 65% when taken 4 times daily. In one study, the probiotic Lactobacillus GG was found to provide 49% protection against traveler' diarrhea, but results with this agent and other probiotics have been highly variable and geographically inconsistent. Tannin albuminate plus ethacridine lactate provided 36% protection, but it is not widely available. Among the nonantimicrobial agents that are available and useful for the treatment of traveler' diarrhea are bismuth subsalicylate—containing preparations, which reduce the passage of loose stools by 16%–18%. The antisecretory and antimotility agent loperamide reduces the passage of loose stools by ∼50% and has been especially useful, in combination with antimicrobial agents, in reducing the total duration of posttreatment diarrhea to a matter of hours.

Journal Article.  5502 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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