Journal Article

Poorly Absorbed Antibiotics for the Treatment of Traveler' Diarrhea

David N. Taylor

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 41, issue Supplement_8, pages S564-S570
Published in print December 2005 | ISSN: 1058-4838
Published online December 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/432953
Poorly Absorbed Antibiotics for the Treatment of Traveler' Diarrhea

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This article describes the use of poorly absorbed antibiotics for the treatment of traveler' diarrhea. Poorly absorbed oral antibiotics can deliver high concentrations of drug to the site of enteric infection with minimal risk of systemic adverse effects, toxicity, and drug interactions. Compared with systemically absorbed oral antibiotics, poorly absorbed oral antibiotics may be less associated with the pressure that leads to the development of bacterial resistance, because they do not affect bacteria outside the gastrointestinal tract. In clinical studies, poorly absorbed oral antibiotics, including aztreonam, bicozamycin, and rifaximin, were more effective than and as well tolerated as placebo; in particular, rifaximin was as effective as oral ciprofloxacin in reducing the duration of illness in traveler' diarrhea. More research is warranted to delineate the effects of poorly absorbed antibiotics in invasive infection and to assess the potential for the development of bacterial resistance.

Journal Article.  4204 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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