Journal Article

Sequelae of Traveler's Diarrhea: Focus on Postinfectious Irritable Bowel Syndrome

Bradley A. Connor

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 41, issue Supplement_8, pages S577-S586
Published in print December 2005 | ISSN: 1058-4838
Published online December 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/432956
Sequelae of Traveler's Diarrhea: Focus on Postinfectious Irritable Bowel Syndrome

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Traveler' diarrhea is usually an acute, self-limited illness; however, in some patients, enteric symptoms can persist for weeks, months, or years. It has been estimated that up to 3% of patients withtraveler' diarrhea have symptoms for >30 days. The differential diagnosis includes persistent infection, coinfection, temporary post infection phenomena, or malabsorptive syndromes. Once these possibilities are excluded, and if symptoms persist, a diagnosis of postinfectious irritable bowel syndrome (PI-IBS) becomes more likely. PI-IBS has recently become a topic of considerable clinical and investigative interest, because evidence validating it as a diagnosis and elucidating its pathophysiological mechanisms has accumulated. Epidemiological evidence suggests that PI-IBS is a relatively common sequel a of acute gastroenteritis. Experimental evidence suggests that chronic inflammation following acute bacterial infection has a pathophysiological role in the development of PI-IBS. A fuller understanding of these pathophysiological mechanisms will lead to a more directed therapeutic approach and, perhaps, are evaluation of prophylaxis fortraveler' diarrhea as a means of primary prevention of PI-IBS.

Journal Article.  6267 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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