Journal Article

Undetectable Plasma HIV RNA Load Predicts Success after Hepatitis B Vaccination in HIV-Infected Persons

Edgar Turner Overton, Somnuek Sungkanuparph, William G. Powderly, Warren Seyfrieds, Richard K. Groger and Judith A. Aberg

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 41, issue 7, pages 1045-1048
Published in print October 2005 | ISSN: 1058-4838
Published online October 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/433180
Undetectable Plasma HIV RNA Load Predicts Success after Hepatitis B Vaccination in HIV-Infected Persons

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Human immunodeficiency virus (HIV)—infected patients respond poorly to hepatitis B vaccination. Records of 194 HIVinfected patients were reviewed for factors associated with successful hepatitis B vaccination. Thirty-four patients (17.5%) developed a protective antibody response. In a logistic regression model, only a plasma HIV RNA level of <400 copies/mL at the time of vaccination was associated with a protective antibody response (P=.003).

Journal Article.  2422 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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