Journal Article

The Pharmacokinetic and Pharmacodynamic Properties of Vancomycin

Michael J. Rybak

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 42, issue Supplement_1, pages S35-S39
Published in print January 2006 | ISSN: 1058-4838
Published online January 2006 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/491712
The Pharmacokinetic and Pharmacodynamic Properties of Vancomycin

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Vancomycin is one of only a few antibiotics available to treat patients infected with methicillin-resistant Staphylococcus aureus and methicillin-resistant, coagulase-negative Staphylococcus species. Therefore, understanding the clinical implications of the pharmacokinetic and pharmacodynamic properties of vancomycin is a necessity for clinicians. Vancomycin is a concentration-independent antibiotic (also referred to as a “time-dependent” antibiotic), and there are factors that affect its clinical activity, including variable tissue distribution, inoculum size, and emerging resistance. This article reviews the pharmacokinetic and pharmacodynamic data related to vancomycin and discusses such clinical issues as toxicities and serum concentration monitoring.

Journal Article.  3686 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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