Journal Article

A Polymorphism of Intercellular Adhesion Molecule–1 Is Associated with a Reduced Incidence of Nonmalarial Febrile Illness in Kenyan Children

Neil E. Jenkins, Tabitha W. Mwangi, Moses Kortok, Kevin Marsh, Alister G. Craig and Thomas N. Williams

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 41, issue 12, pages 1817-1819
Published in print December 2005 | ISSN: 1058-4838
Published online December 2005 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/498156
A Polymorphism of Intercellular Adhesion Molecule–1 Is Associated with a Reduced Incidence of Nonmalarial Febrile Illness in Kenyan Children

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An intercellular adhesion molecule–1 polymorphism (ICAM-1Kilifi) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule–1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1Kilifi. We propose that ICAM-1Kilifi may be associated with reduced rates of tissue damage and of death due to sepsis.

Journal Article.  1570 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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