Journal Article

Dihydropteroate Synthase Mutations in the <i>folP1</i> Gene Predict Dapsone Resistance in Relapsed Cases of Leprosy

Emmanuelle Cambau, Laetitia Carthagena, Aurélie Chauffour, Baohong Ji and Vincent Jarlier

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 42, issue 2, pages 238-241
Published in print January 2006 | ISSN: 1058-4838
Published online January 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/498506
Dihydropteroate Synthase Mutations in the folP1 Gene Predict Dapsone Resistance in Relapsed Cases of Leprosy

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Molecular detection was compared with the mouse footpad inoculation test for detection of dapsone resistance in 38 strains of Mycobacterium leprae. Mutations of the folP1 gene (at codons 53 or 55) were found in 6 of 6 strains with high-level resistance, in 3 of 4 strains with intermediate-level resistance, and in 1 of 6 strains with low-level resistance, but not in 22 dapsone-susceptible strains. In cases of infection with strains of M. leprae carrying the folP1 mutation, therapy with dapsone may be replaced by therapy with a fluoroquinolone.

Journal Article.  2640 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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