Journal Article

Immunotherapy for Fungal Infections

Brahm H. Segal, June Kwon-Chung, Thomas J. Walsh, Bruce S. Klein, Minoo Battiwalla, Nikolaos G. Almyroudis, Steven M. Holland and Luigina Romani

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 42, issue 4, pages 507-515
Published in print February 2006 | ISSN: 1058-4838
Published online February 2006 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/499811
Immunotherapy for Fungal Infections

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Opportunistic fungal infections are major causes of morbidity and mortality among immunocompromised individuals. Fungi have evolved complex and coordinated mechanisms to survive in the environment and in the mammalian host. Fungi must adapt to “stressors” in the host (including scarcity of nutrients, pH, and reactive oxygen and nitrogen intermediates) in addition to evading host immunity. Knowledge of the immunopathogenesis of fungal infections has paved the way to promising strategies for immunotherapy. These include strategies that increase phagocyte number, activate innate host defense pathways in phagocytes and dendritic cells, and stimulate antigen-specific immunity (e.g., vaccines). Immunotherapy must be tailored to specific immunocompromised states. Challenges exist in bringing promising immunotherapies from the laboratory to clinical trials.

Journal Article.  6187 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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