Journal Article

Persistent Neuroinvasive West Nile Virus Infection in an Immunocompromised Patient

Robert G. Penn, Jeannette Guarner, James J. Sejvar, Herbert Hartman, Rodney D. McComb, Diana L. Nevins, Julu Bhatnagar and Sherif R. Zaki

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 42, issue 5, pages 680-683
Published in print March 2006 | ISSN: 1058-4838
Published online March 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/500216
Persistent Neuroinvasive West Nile Virus Infection in an Immunocompromised Patient

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A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were detected. This patient's case raises important issues related to the diagnosis, pathogenesis, and possible treatment of persistent WNV infection.

Journal Article.  2226 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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