Journal Article

Enhanced Invasiveness of Bovine-Derived Neonatal Sequence Type 17 Group B <i>Streptococcus</i> Is Independent of Capsular Serotype

Nicola Jones, Karen A. Oliver, Joanne Barry, Rosalind M. Harding, Naiel Bisharat, Brian G. Spratt, Tim Peto and Derrick W. Crook

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 42, issue 7, pages 915-924
Published in print April 2006 | ISSN: 1058-4838
Published online April 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/500324
Enhanced Invasiveness of Bovine-Derived Neonatal Sequence Type 17 Group B Streptococcus Is Independent of Capsular Serotype

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Background. A defined geographical area (Oxford, United Kingdom) was investigated for the role of group B Streptococcus (GBS) as a human pathogen.

Methods. GBS carriage in pregnant women and invasive disease in neonates and adults >60 years of age was studied over a 3-year period. Multilocus sequence typing and capsular serotyping were used to study 369 isolates of GBS from carriage in pregnant women (n = 190) and invasive disease in neonates (n = 109) and adults >60 years of age (n = 70).

Results. A total of 20.3% of pregnant women carried GBS. Invasive GBS disease occurred at a rate of 0.9 cases per 1000 live births and 11 cases per 100,000 population >60 years of age per annum. Four sequence types (STs) (ST-17, ST-19, ST-23, and ST-1) that were identified with use of multilocus sequence typing accounted for >50% of carried and invasive strains. A single sequence type (ST-17), previously shown to be phylogenetically of bovine origin, was significantly associated with increased invasiveness in neonates (P = .00002), and this was independent of capsular serotype III. In contrast, among adults >60 years of age, no STs exhibited increased invasiveness, compared with STs carried in pregnant women.

Conclusions. Enhanced invasiveness associated with ST-17 is specific to neonates and is independent of capsular serotype.

Journal Article.  4450 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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