Journal Article

Human Cytomegalovirus–Encoded α-Chemokines Exhibit High Sequence Variability in Congenitally Infected Newborns

Ravit Arav-Boger, Charles B. Foster, Jian-Chao Zong and Robert F. Pass

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 193, issue 6, pages 788-791
Published in print March 2006 | ISSN: 0022-1899
Published online March 2006 | e-ISSN: 1537-6613 | DOI: http://dx.doi.org/10.1086/500508
Human Cytomegalovirus–Encoded α-Chemokines Exhibit High Sequence Variability in Congenitally Infected Newborns

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Most congenital human cytomegalovirus (HCMV) infections are asymptomatic, but some lead to severe disease. We hypothesized that differences in disease manifestations may be partially explained by differences in viral strains. We recently reported an association between unique long (UL) 144 gene polymorphisms and clinical disease. We now report on the sequence heterogeneity of 2 potential HCMV virulence genes that encode α-chemokines: UL146 and UL147. These 2 genes were highly divergent in cultured isolates obtained from 23 newborns with congenital HCMV infection and were difficult to categorize. Unlike our findings for the contiguous UL144 gene, no specific UL146 or UL147 genotype was associated with disease outcome

Journal Article.  2674 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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