Journal Article

Endothelial Function in HIV-Infected Persons

Anthony Solages, Joseph A. Vita, David J. Thornton, Jessica Murray, Timothy Heeren, Donald E. Craven and C. Robert Horsburgh

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 42, issue 9, pages 1325-1332
Published in print May 2006 | ISSN: 1058-4838
Published online May 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/503261
Endothelial Function in HIV-Infected Persons

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  • Infectious Diseases
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Background. Several reports have suggested an increased risk of coronary disease in human immunodeficiency virus (HIV)–infected patients receiving protease inhibitors (PIs). Impaired endothelium-dependent vasodilation is a putative surrogate marker of coronary atherosclerotic disease.

Methods. The present study evaluated the effect of HIV infection and antiretroviral treatment on endothelial vasomotor function, by assessing brachial artery flow-mediated dilation (FMD). A total of 75 HIV-infected patients were compared with 223 control subjects who were presumed to be HIV uninfected.

Results. HIV-infected patients had significantly impaired FMD, compared with control subjects (mean ± SD, 7.3% ± 4.4% vs. 11.1% ± 6.3%; P < .0001). When adjustments were made for smoking status, sex, and body mass index, the difference between the 2 groups remained statistically significant (P < .01). In a cross-sectional analysis of the HIV-infected patients, we found significant associations between FMD and current injection drug use, hazardous drinking, HIV load, and α–high-density lipoprotein triglyceride levels, but not PI therapy. In a multivariate analysis, only current injection drug use and a lower α–high-density lipoprotein triglyceride level were significantly associated with FMD.

Conclusions. HIV-infected patients have significant impairment of endothelial function, and this impairment is worse among those with elevated levels of HIV replication, particularly injection drug users.

Journal Article.  4095 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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