Journal Article

Lactic Acidosis in Gabonese Children with Severe Malaria Is Unrelated to Dehydration

J. N. Jarvis, T. Planche, T. Bicanic, A. Dzeing-Ella, M. Kombila, S. Issifou, S. Borrmann, P. G. Kremsner and S. Krishna

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 42, issue 12, pages 1719-1725
Published in print June 2006 | ISSN: 1058-4838
Published online June 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/504329
Lactic Acidosis in Gabonese Children with Severe Malaria Is Unrelated to Dehydration

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Background. Hyperlactatemia is an important and common complication of severe malaria. We investigated changes in fluid compartment volumes in patients with severe malaria and control patients with the use of bioimpedence analysis.

Methods. We estimated extracellular water and total body water volumes in a total of 180 children: 56 with severe malaria, 94 with moderate malaria, 24 with respiratory tract infection, and 6 with severe diarrhea.

Results. There was a mean (±SD) decrease in total body water volume of 17 ± 24 mL/kg (or 3% of total body water volume) in patients with severe malaria. This compares with a mean (±SD) decrease in total body water volume of 33 ± 28 mL/kg (or 6% of total body water volume) in patients with severe diarrhea. There was no increase in extracellular water volume in patients with severe malaria, suggesting no significant intravascular volume depletion in patients with severe malaria. There was no relationship between lactatemia and any changes in fluid compartment volumes.

Conclusions. The changes in fluid volumes that were observed are unlikely to be of physiological significance in the pathophysiology of severe malaria.

Journal Article.  3826 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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