Journal Article

The Epidemiological Profile of Infections with Multidrug-Resistant <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter</i> Species

David L. Paterson

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 43, issue Supplement_2, pages S43-S48
Published in print September 2006 | ISSN: 1058-4838
Published online September 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/504476
The Epidemiological Profile of Infections with Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter Species

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Isolates of Pseudomonas aeruginosa or Acinetobacter species that are resistant to all, or almost all, commercially available antibiotics are now prevalent worldwide. Typically, these strains are recovered from patients in intensive care units who have ventilator-associated pneumonia. “Panresistant” strains can be defined as strains that are resistant to all β-lactam and quinolone antibiotics recommended as empirical therapy for ventilator-associated pneumonia. These strains are well adapted to the hospital environment—molecular epidemiological studies have frequently revealed that only 1 or 2 clones caused outbreaks in intensive care units. However, panresistant strains may also be selected by antibiotic use. Given the lack of antibiotic options to treat infection with panresistant strains, enhanced surveillance for these organisms is necessary at unit-specific, institutional, and national levels.

Journal Article.  4082 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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