Journal Article

Contemporary Tools for the Diagnosis and Management of Invasive Mycoses

Barbara D. Alexander and Michael A. Pfaller

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 43, issue Supplement_1, pages S15-S27
Published in print August 2006 | ISSN: 1058-4838
Published online August 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/504491
Contemporary Tools for the Diagnosis and Management of Invasive Mycoses

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Invasive fungal infections have become a major cause of morbidity and mortality over the past 3 decades. Organ transplantation, the use of aggressive chemotherapy, and the availability and widespread use of immunosuppressive treatments for many medical ailments have resulted in large populations of patients who are at risk for fungal disease. Early diagnosis and prompt therapy are instrumental to successful treatment of these infections, but conventional methods for diagnosis of fungal disease are slow and lack sensitivity. Important advances in diagnosing invasive mycoses, particularly in laboratory-based testing, have been realized over the years. Antigen-based assays, new laboratory methods for identification of fungi, and reference guidelines for susceptibility testing have been developed and validated for use in clinical laboratories. We review these technological advances and our understanding of their clinical application and impact.

Journal Article.  9759 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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